Volume 17, Issue 6 (November 2015) 17, 961–971; 10.4103/1008-682X.159721
Transcriptome research on spermatogenic molecular drive in mammals
Zi-Jue Zhu, Shi Yang, Zheng Li
Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127; Department of Andrology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China
Correspondence: Prof. Z Li
It is known that spermatogenic disorders are associated with genetic deficiency, although the primary mechanism is still unclear.
It is difficult to demonstrate the molecular events occurring in testis, which contains germ cells at different developmental stages.
However, transcriptomic methods can help us reveal the molecular drive of male gamete generation. Many transcriptomic studies
have been performed on rodents by utilizing the timing of the first wave of spermatogenesis, which is not a suitable strategy for
research in fertile men. With the development of separation methods for male germ cells, transcriptome research on the molecular
drive of spermatogenesis in human men has seen great progress, and the results could be ultimately applied to improve the
diagnosis and treatment for male infertility.
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