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Abstract

Volume 22, Issue 5 (September 2020) 22, 519–525; 10.4103/aja.aja_117_19

Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer

Sha Zhu, Jin-Ge Zhao, Jun-Ru Chen, Zhen-Hua Liu, Guang-Xi Sun, Zhi-Peng Wang, Yu-Chao Ni, Jin-Dong Dai, Peng-Fei Shen, Hao Zeng

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China

Correspondence: Dr. H Zeng (kucaizeng@163.com) or Dr. PF Shen (cdhx510@163.com)

Date of Submission 09-Feb-2019 Date of Acceptance 01-Sep-2019 Date of Web Publication 08-Nov-2019

Abstract

Intraductal carcinoma of the prostate (IDC-P) is an aggressive pathological pattern of prostate cancer (PCa). We investigated the association of IDC-P in prostate biopsy (PBx) with several pathological features after radical prostatectomy (RP) and its prognostic value in high-risk PCa. A total of 418 patients with high-risk PCa after RP were included in this study. IDC-P and its architectural patterns were identified according to the 2016 World Health Organization Classification. Chi-squared test and logistic regression were used to investigate the correlation between IDC-P and post-RP pathological features. Kaplan–Meier curves and Cox regression were applied to explore the prognostic value of IDC-P. IDC-P was identified in PBx in 36/418 (8.6%) patients. Logistic regression indicated that IDC-P in PBx was independently associated with several pathological features of RP, including Gleason score 8–10 (P < 0.001), seminal vesicular invasion (P < 0.001), and pathological T (pT) 3a (P = 0.043). Patients with IDC-P in PBx manifested poorer biochemical-free survival (BFS) than those without IDC-P (37.47 months vs not reached, P < 0.001). The addition of IDC-P in several prognostic nomograms could improve the predictive accuracy of these tools. We conclude that IDC-P in PBx is positively associated with several aggressive pathological features after RP in high-risk PCa. In addition, IDC-P in PBx could effectively predict the BFS of high-risk PCa patients after RP.

Keywords: biopsy; high risk; intraductal carcinoma of the prostate; prognosis; prostate cancer

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