Volume 20, Issue 2 (March 2018) 20, 166–172; 10.4103/aja.aja_49_17
Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis
Kai Cui1,2, Zhe Tang1,2, Chuan-Chang Li1,2, Tao Wang1,2, Ke Rao1,2, Shao-Gang Wang1,2, Ji-Hong Liu1,2, Zhong Chen1,2
1 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Correspondence: Dr. JH Liu (jhliu@tjh.tjmu.edu.cn) or Dr. Z Chen (chenzhongtj@126.com)
Date of Submission 18-Jun-2017 Date of Acceptance 08-Sep-2017 Date of Web Publication 07-Nov-2017
Abstract |
Previous studies have shown that oxidative stress and corporal fibrosis in penile tissues of rats were key pathological factors of erectile dysfunction induced by diabetic mellitus (DMED). Lipoxin A4 (LXA4) was reported to inhibit oxidative stress and fibrosis diseases, while whether it could exert a protective role on erectile function was not clear. Type I diabetic mellitus (DM) was induced in thirty male 10-week-old Sprague-Dawley rats using streptozotocin. Ten weeks later, twenty-two rats with DMED confirmed by an apomorphine test were divided into two groups: the DMED group (n = 11) and the DMED + LXA4 group (n = 11; LXA4 injection daily for 4 weeks). In addition, another ten age-matched rats formed the Control group. We found that erectile function was significantly impaired in the DMED group compared with the Control group, but was improved in the DMED + LXA4 group. Similarly, the over-activated oxidative stress and impaired endothelial function in the DMED group were both improved in the DMED + LXA4 group. Moreover, the DMED group showed serious corporal fibrosis, which was also inhibited by the treatment of LXA4 in the DMED + LXA4 group. Taken together, LXA4 could exert an inhibition role on oxidative stress and fibrosis to improve DMED effectively.
Keywords: diabetic mellitus; erectile dysfunction; fibrosis; oxidative stress
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