Home  |   Archive  |   Online Submission  |   News & Events  |   Subscribe  |   APFA  |   Society  |   Contact Us  |   中文版
Search   
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

 
Abstract

Volume 20, Issue 3 (May 2018) 20, 265–269; 10.4103/aja.aja_60_17

Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma

Jin-You Wang1, Ming-Zhu Gao2, De-Xin Yu1, Dong-Dong Xie1, Yi Wang1, Liang-Kuan Bi1, Tao Zhang1, De-Mao Ding1

1 Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
2 Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China

Correspondence: Dr. DX Yu (yudx_urology@126.com)

Date of Submission 13-Jun-2017 Date of Acceptance 26-Oct-2017 Date of Web Publication 29-Dec-2017

Abstract

The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis (ILNM) in patients with penile squamous cell carcinoma (PSCC). The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization (WHO) histopathological classification. We retrieved the clinicopathological factors from the medical records including age, clinical lymph node stage, pathological tumor stage, lymphatic invasion, and nerve invasion. Uni- and multivariate logistic regression analyses were used to explore the risk factors of ILNM. Multivariate analyses identified clinical lymph node stage (P = 0.000), pathological tumor stage (P = 0.016), histologic grade (P = 0.000), and risk group of histological subtypes (P = 0.029) as independent predictors for ILNM. Compared with the low-risk group of PSCC subtypes, the intermediate- (HR: 3.66, 95% CI: 1.30–10.37, P = 0.021) and high-risk groups (HR: 28.74, 95% CI: 2.37–348.54, P = 0.008) were significantly associated with ILNM. In conclusion, the histopathological subtype of the primary lesion is a significant predictor for ILNM in patients with PSCC.

Keywords: histopathological subtype; inguinal lymph node metastasis; penile neoplasm; squamous cell carcinoma

Full Text | PDF |

 
Browse:  2096
 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.