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Volume 23, Issue 3 (May 2021) 23, 319–324; 10.4103/aja.aja_71_20

Is mild erectile dysfunction associated with severe psychological symptoms in Chinese patients with moderate-to-severe chronic prostatitis/chronic pelvic pain syndrome?

Xiu-Cheng Li1, Xiao-Bo Zhang2, Zhang-Cheng Liao1, Zheng-Yan Tang1,3, Dong-Jie Li2,4,5,6

1 Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China
2 Xiangya International Medical Center, Department of Geriatric Urology, Xiangya Hospital, Central South University, Changsha 410008, China
3 Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease, Changsha 410008, China
4 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
5 Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
6 National Clinical Research Center for Geriatric Disorders, Changsha 410008, China

Correspondence: Dr. DJ Li (dongjieli@csu.edu.cn) or Dr. ZY Tang (xytzyan@163.com)

Date of Submission 03-Mar-2020 Date of Acceptance 02-Aug-2020 Date of Web Publication 17-Nov-2020


This study aimed to assess the association between psychological disorders and erectile dysfunction (ED) in patients with different degrees of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). This was a retrospective study conducted from June 2017 to October 2019 and included 182 outpatients. Patients were interviewed using the Structured Interview on Erectile Dysfunction (SIEDY) for pathogenic quantification. The National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Index of Erectile Function-5 (IIEF-5) were used for the evaluation of CP/CPPS and ED. The Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) were used to assess anxiety symptoms and depressive symptoms. The number of patients with mild CP/CPPS and mild ED, mild CP/CPPS and moderate-to-severe ED, moderate-to-severe CP/CPPS and mild ED, and moderate-to-severe CP/CPPS and moderate-to-severe ED was 69 (37.9%), 36 (19.8%), 35 (19.2%), and 42 (23.1%), respectively. The corresponding PHQ-9 scores of the four groups were 6.22, 7.19, 10.69, and 7.71, respectively. The corresponding GAD-7 scores of the four groups were 5.26, 6.31, 8.77, and 6.36, respectively. Among patients with moderate-to-severe CP/CPPS, the PHQ-9 and GAD-7 scores of the moderate-to-severe ED group were significantly lower than those of the mild ED group (P = 0.007 and P = 0.010, respectively). The prevalence of ED and premature ejaculation (PE) in patients with moderate-to-severe CP/CPPS was significantly higher than that in patients with mild CP/CPPS (P = 0.001 and P = 0.024, respectively). Our findings proved that the severity of ED was negatively associated with psychological symptoms in outpatients with moderate-to-severe CP/CPPS.

Keywords: anxiety; association; chronic prostatitis/chronic pelvic pain syndrome; depression; erectile dysfunction

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