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Abstract

Volume 23, Issue 4 (July 2021) 23, 348–356; 10.4103/aja.aja_80_20

Testosterone, cardiomyopathies, and heart failure: a narrative review

Rodica Diaconu1, Ionuţ Donoiu1, Oana Mirea1, Tudor Adrian Bălşeanu2

1 Department of Cardiology, University of Medicine and Pharmacy, Craiova 200349, Romania
2 Department of Physiology, University of Medicine and Pharmacy, Craiova 200349, Romania

Correspondence: Dr. I Donoiu (ionut.donoiu@umfcv.ro)

Date of Submission 03-Jun-2020 Date of Acceptance 05-Nov-2020 Date of Web Publication 12-Jan-2021

Abstract

Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.

Keywords: androgens; cardiomyocytes; heart disease; myocardial; prognosis

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