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Abstract

Volume 23, Issue 6 (November 2021) 23, 549–554; 10.4103/aja202156

The role of retinoic acid in the commitment to meiosis

Rachel L Gewiss, M Christine Schleif, Michael D Griswold

School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA

Correspondence: Dr. MD Griswold (mgriswold@wsu.edu)

Date of Submission 16-Apr-2021 Date of Acceptance 28-Jun-2021 Date of Web Publication 27-Aug-2021

Abstract

Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in meiosis, as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and completion. Here, we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8 (STRA8) and MEIOSIN, which are responsive to RA and are critical for meiosis. We assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.

Keywords: meiosis; retinoic acid; spermatogenesis; testis

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