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Volume 24, Issue 5 (September 2022) 24, 441–444; 10.4103/aja202225

Evaluation of inactivated COVID-19 vaccine on semen parameters in reproductive-age males: a retrospective cohort study

Hong Zhu1, Xiao Wang1, Feng Zhang1, Yong Zhu1, Mei-Rong Du2, Zhi-Wen Tao1, Can Sun1, Hai-Tao Ma1, Ya-Dong Li1, Guo-Qing Liang1, Jie Ren1, Bai-Lan Feng1, Feng Jiang3

1 Human Sperm Bank, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
2 Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
3 Department of Andrology, Shanghai Ji Ai Genetics and IVF institute China-USA Center, Shanghai 200011, China

Correspondence: Dr. BL Feng (fengbailan7429@fckyy.org.cn) or Dr. F Jiang (jfsy001@163.com)

Date of Submission 17-Jan-2022 Date of Acceptance 25-Mar-2022 Date of Web Publication 03-May-2022


During the coronavirus disease (COVID-19) epidemic, there have been concerns about the impact of vaccines on people's fertility, including the fertility of those who are currently preparing for pregnancy and those who might become pregnant in future. However, there is still a lack of research on the effect of the COVID-19 vaccine on male fertility, and it is not surprising that couples and donors have concerns regarding vaccination. In this study, a retrospective cohort study was conducted to examine semen quality before and after receipt of the inactivated COVID-19 vaccine. There were no statistically significant changes in semen parameters (volume, sperm concentration, progressive motility, and total progressive motile count) after two doses of vaccine (all P > 0.05). In summary, our study updates the most recent studies on the effects of the COVID-19 vaccine on male fertility, and the information from this study could be used to guide fertility recommendations for assisted reproductive technology (ART) patients and donors.

Keywords: assisted reproductive technology; coronavirus disease vaccine; male fertility; semen parameters; sperm donation

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