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Volume 25, Issue 2 (March 2023) 25, 184–191; 10.4103/aja202255

Circadian rhythm in prostate cancer: time to take notice of the clock

Wei-Zhen Zhu, Qi-Ying He, De-Chao Feng, Qiang Wei, Lu Yang

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China

Correspondence: Dr. Q Wei (weiqiang933@126.com) or Dr. L Yang (wycleflue@163.com)

Received: 03 April 2022; Accepted: 04 July 2022; published online: 06 September 2022


The circadian clock is an evolutionary molecular product that is associated with better adaptation to changes in the external environment. Disruption of the circadian rhythm plays a critical role in tumorigenesis of many kinds of cancers, including prostate cancer (PCa). Integrating circadian rhythm into PCa research not only brings a closer understanding of the mechanisms of PCa but also provides new and effective options for the precise treatment of patients with PCa. This review begins with patterns of the circadian clock, highlights the role of the disruption of circadian rhythms in PCa at the epidemiological and molecular levels, and discusses possible new approaches to PCa therapy that target the circadian clock.

Keywords: chronotherapy; circadian clock; circadian rhythm; prostate cancer

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.