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Abstract

Volume 25, Issue 3 (May 2023) 25, 287–295; 10.4103/aja202259

FOXA1 in prostate cancer

Hui-Yu Dong1,2, Lei Ding1, Tian-Ren Zhou1, Tao Yan1, Jie Li1, Chao Liang1

1 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2 Department of Clinical Medicine, Suzhou Vocational Health College, Suzhou 215009, China

Correspondence: Dr. C Liang (lc_machine@163.com) or Dr. J Li (drc_lijie@126.com)

Received: 08 April 2022; Accepted: 07 June 2022; Published online: 19-Aug-2022

Abstract

Most prostate cancers initially respond to androgen deprivation therapy (ADT). With the long-term application of ADT, localized prostate cancer will progress to castration-resistant prostate cancer (CRPC), metastatic CRPC (mCRPC), and neuroendocrine prostate cancer (NEPC), and the transcriptional network shifted. Forkhead box protein A1 (FOXA1) may play a key role in this process through multiple mechanisms. To better understand the role of FOXA1 in prostate cancer, we review the interplay among FOXA1-targeted genes, modulators of FOXA1, and FOXA1 with a particular emphasis on androgen receptor (AR) function. Furthermore, we discuss the distinct role of FOXA1 mutations in prostate cancer and clinical significance of FOXA1. We summarize possible regulation pathways of FOXA1 in different stages of prostate cancer. We focus on links between FOXA1 and AR, which may play different roles in various types of prostate cancer. Finally, we discuss FOXA1 mutation and its clinical significance in prostate cancer. FOXA1 regulates the development of prostate cancer through various pathways, and it could be a biomarker for mCRPC and NEPC. Future efforts need to focus on mechanisms underlying mutation of FOXA1 in advanced prostate cancer. We believe that FOXA1 would be a prognostic marker and therapeutic target in prostate cancer.

Keywords: androgen receptor; forkhead box protein A1; mutation; prostate cancer

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.