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Abstract

Volume 25, Issue 3 (May 2023) 25, 345–349; 10.4103/aja202264

Outcomes of radical prostatectomy in a 20-year localized prostate cancer single institution series in China

Xiao-Hao Ruan1,2, Tsun Tsun Stacia Chun1,3, Da Huang1,2, Hoi-Lung Wong3, Brian Sze-Ho Ho1,3, Chiu-Fung Tsang1,3, Terence Chun-Ting Lai1,3, Ada Tsui-Lin Ng1,3, Rong Na1,3, James Hok-Leung Tsu1,3

1 Division of Urology, Department of Surgery, The University of Hong Kong, Hong Kong, China
2 Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3 Division of Urology, Department of Surgery, Queen Mary Hospital, Hong Kong, China

Correspondence: Dr. JHL Tsu (thl589@ha.org.hk) or Dr. R Na (narong.hs@gmail.com)

13-Sep-2022

Abstract

The long-term survival outcomes of radical prostatectomy (RP) in Chinese prostate cancer (PCa) patients are poorly understood. We conducted a single-center, retrospective analysis of patients undergoing RP to study the prognostic value of pathological and surgical information. From April 1998 to February 2022, 782 patients undergoing RP at Queen Mary Hospital of The University of Hong Kong (Hong Kong, China) were included in our study. Multivariable Cox regression analysis and Kaplan–Meier analysis with stratification were performed. The 5-year, 10-year, and 15-year overall survival (OS) rates were 96.6%, 86.8%, and 70.6%, respectively, while the 5-year, 10-year, and 15-year PCa-specific survival (PSS) rates were 99.7%, 98.6%, and 97.8%, respectively. Surgical International Society of Urological Pathology PCa grades (ISUP Grade Group) ≥4 was significantly associated with poorer PSS (hazard ratio [HR] = 8.52, 95% confidence interval [CI]: 1.42–51.25, P = 0.02). Pathological T3 stage was not significantly associated with PSS or OS in our cohort. Lymph node invasion and extracapsular extension might be associated with worse PSS (HR = 20.30, 95% CI: 1.22–336.38, P = 0.04; and HR = 7.29, 95% CI: 1.22–43.64, P = 0.03, respectively). Different surgical approaches (open, laparoscopic, or robotic-assisted) had similar outcomes in terms of PSS and OS. In conclusion, we report the longest timespan follow-up of Chinese PCa patients after RP with different approaches.

Keywords: China; oncologic outcome; prostate cancer; radical prostatectomy

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.