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Volume 25, Issue 3 (May 2023) 25, 339–344; 10.4103/aja202268
Association between semen collection time and semen parameters: an observational study
Bai, Shun1; Dou, Xian-Chao2; Qi, Hao-Lin3; Zhu, Yan-Song4; Zhang, Yin-Tao5; Liu, Yi-Xun6; Hu, Xue-Chun6; Cao, Cheng1; Tong, Xian-Hong1; Xu, Bo1; Wu, Li-Min1,; Jiang, Xiao-Hua1
1Reproductive and Genetic Hospital, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
2School of Medical Imaging, Bengbu Medical University, Bengbu 233030, China
3The First Clinical Medical School, Anhui Medical University, Hefei 230022, China
4School of Life Science, Anhui Medical University, Hefei 230022, China
5Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei 230022, China
6Department of Urology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
Correspondence: Dr. LM Wu (wuliminmail@126.com) or Dr. XH Jiang (biojxh@ustc.edu.cn)
Received: 08 February 2022; Accepted: 09 August 2022; published online: 04 October 2022
| Abstract |
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The process of semen collection plays a key role in the quality of semen specimens. However, the association between semen
collection time and semen quality is still unclear. In this study, ejaculates by masturbation from 746 subfertile men or healthy
men who underwent semen analysis were examined. The median (interquartile range) semen collection time for all participants
was 7.0 (5.0–11.0) min, and the median time taken for semen collection was lower in healthy men than that in subfertile men
(6.0 min vs 7.0 min). An increase in the time required to produce semen samples was associated with poorer semen quality. Among
those undergoing assisted reproductive technology (ART), the miscarriage rate was positively correlated with the semen collection
time. After adjusting for confounders, the highest quartile (Q4) of collection time was negatively associated with semen volume
and sperm concentration. A longer time to produce semen samples (Q3 and Q4) was negatively correlated with progressive and
total sperm motility. In addition, there was a significant negative linear association between the semen collection time and the
sperm morphology. Higher risks of asthenozoospermia (adjusted odds ratio [OR] = 2.06, 95% confidence interval [CI]: 1.31–3.25,
P = 0.002) and teratozoospermia (adjusted OR = 1.98, 95% CI: 1.10–3.55, P = 0.02) were observed in Q3 than those in Q1.
Our results indicate that a higher risk of abnormal semen parameter values was associated with an increase in time for semen
collection, which may be related to male fertility through its association with semen quality.
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