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Volume 18, Issue 6 (November 2016) 18, 908–912; DOI:10.4103/1008-682X.167720

Comparison of quercetin and resveratrol in the prevention of injury due to testicular torsion/detorsion in rats

Kai-Kai Chi, Wen-Hui Zhang, Zhu Chen, Yong Cui, Wei He, Suo-Gang Wang, Chan Zhang, Jie Chen, Guang-Ce Wang

1 Department of Urology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China
2 Department of Hematology, Henan Provincial People's Hospital, Zhengzhou 450002, Henan, China

Correspondence: Dr. GC Wang (wgc460@medmail.com.cn)

Date of Submission 21-Mar-2015 Date of Decision 23-Apr-2015 Date of Acceptance 06-Sep-2015 Date of Web Publication 27-Nov-2015



Quercetin (QE) and resveratrol (RSV) are powerful antioxidants with the potential to protect the testes against ischemia/reperfusion (I/R) injury. We compared their effects in testicular torsion/detorsion (T/D) in adult rats. Twenty-four male Wistar rats were divided into four groups: sham (group A), T/D (group B), T/D treated with QE (group C), and T/D treated with RSV (group D). QE (20 mg kg−1 ) and RSV (20 mg kg−1 ) were injected intra-peritoneally at 60 min of torsion. After 90 min of surgically induced torsion, the testicular cord was restored to its anatomical position. Twenty-four hour after torsion, blood and tissue samples were obtained for further examination. Testicular tissue malondialdehyde (MDA) and nitric oxide (NO) levels and serum total oxidant status (TOS) were higher in group B than in group A (P < 0.05). Group A had higher serum total antioxidant status (TAS) than group B. (P < 0.05) QE and RSV significantly lowered MDA, NO, and TOS levels and TAS consumption (P < 0.05). QE reduced the MDA and TOS levels more than RSV (P < 0.05), but their effects on NO reduction and TAS consumption were similar (P > 0.05). Group A had normal testicular architecture (grade 1). Groups C (mean grade 2.60) and D (mean grade 3.00) had lower testicular injury grades than group B (mean grade 3.45) (P < 0.05). Group C had lower testicular injury grade than group D (P < 0.05). Treatment with QE and RSV protects against I/R injury after testicular T/D. QE may exhibit better function than RSV at the doses tested in this study.

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