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Volume 19, Issue 2 (March 2017) 19, 160–167; DOI:10.4103/1008-682X.170436

Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old Mongolian gerbils

Manoel F Biancardi, Ana PS Perez, Cássia RS Caires, Luiz R Falleiros, Rejane M Góes, Patrícia SL Vilamaior, Diógenes R Freitas, Fernanda CA Santos, Sebastião R Taboga

1Department of Structural and Functional, State University of Campinas, Av. Bertrand Russel s/n, Campinas, São Paulo, 13084864, Brazil; 3University Estadual
Paulista – UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo, 15054000,
Brazil; 4Medical School, Federal University of Goiás, Colemar Natal e Silva, Goiania, Goiás, 74001970, Brazil; 2Department of Histology, Embryology and Cell Biology,
Federal University of Goiás, Samambaia II, Goiania, Goiás, 74001970, Brazil.

Correspondence: Dr. SR Taboga (taboga@ibilce.unesp.br)

Date of Submission 24-Mar-2015 Date of Decision 24-Jun-2015 Date of Acceptance 30-Oct-2015 Date of Web Publication 19-Jan-2016


The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may
disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins
of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood.
Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and
postnatal life using morphological, biometrical, stereological, Kariometric, immunohistochemical, and immunofluorescence analyses.
Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development
of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia
in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are
important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging.
Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during
prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

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