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Abstract

Volume 18, Issue 5 (September 2016) 18, 673–681; DOI:10.4103/1008-682X.181817

Molecular signalling involving intrinsically disordered proteins in prostate cancer

Anna Russo, Sara La Manna, Ettore Novellino, Anna Maria Malfitano, Daniela Marasco

Department of Pharmacy, Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples "Federico II", 80134 Naples, Italy

Correspondence: Dr. D Marasco (daniela.marasco@unina.it)

20-May-2016

Abstract

Investigations on cellular protein interaction networks (PINs) reveal that proteins that constitute hubs in a PIN are notably enriched in Intrinsically Disordered Proteins (IDPs) compared to proteins that constitute edges, highlighting the role of IDPs in signaling pathways. Most IDPs rapidly undergo disorder-to-order transitions upon binding to their biological targets to perform their function. Conformational dynamics enables IDPs to be versatile and to interact with a broad range of interactors under normal physiological conditions where their expression is tightly modulated. IDPs are involved in many cellular processes such as cellular signaling, transcriptional regulation, and splicing; thus, their high-specificity/low-affinity interactions play crucial roles in many human diseases including cancer. Prostate cancer (PCa) is one of the leading causes of cancer-related mortality in men worldwide. Therefore, identifying molecular mechanisms of the oncogenic signaling pathways that are involved in prostate carcinogenesis is crucial. In this review, we focus on the aspects of cellular pathways leading to PCa in which IDPs exert a primary role.

Keywords: inflammation; intrinsically disordered proteins; prostate cancer

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