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10.4103/aja202560
Impact of semen quality and maternal age on blastocyst chromosomal abnormalities: a retrospective cohort study based on 1091 PGT-A cycles
Zou, Yang1,2,3,4,5,6,7,*; Xu, Xin8,9,*; Xie, Hong-Qiang1,2,3,4,5,6,7; Gao, Ming1,2,3,4,5,6,7; Liu, Xiao-Wei1,2,3,4,5,6,7; Wang, Li-Juan1,2,3,4,5,6,7; Li, Cheng1,2,3,4,5,6,7; Jing, Tao8,9; Gao, Xuan1,2,3,4,5,6,7; Yan, Jun-Hao1,2,3,4,5,6,7; Chen, Zi-Jiang1,2,3,4,5,6,7,10,11; Gao, Yuan1,2,3,4,5,6,7
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China
2National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China
3Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan 250012, China
4Shandong Technology Innovation Center for Reproductive Health, Jinan 250012, China
5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, China
6Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention, Jinan 250012, China
7Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences, Jinan 250012, China
8Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510220, China
9Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510220, China
10Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200127, China
11Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Correspondence: Dr. Y Gao (gaoyuan@sduivf.com)
Received: 05 March 2025; Accepted: 23 June 2025; published online: 13 January 2026
| Abstract |
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In this study, we aimed to investigate the influence of paternal oligozoospermia (OZ), asthenozoospermia (AZ), or teratozoospermia (TZ) on blastocyst ploidy and its potential interaction with maternal age. We analyzed 3383 embryos in 1091 preimplantation genetic testing for aneuploidy (PGT-A) cycles via next-generation sequencing (NGS) at the Center for Reproductive Medicine, Shandong University (Jinan, China). Our findings revealed that compared to the normozoospermic (NZ) group, the AZ group exhibited significantly lower euploidy rates (P = 0.022). This effect was more pronounced in cases with advanced maternal age (AMA; ≥38 years), where AZ patients had markedly reduced euploidy rates (P = 0.003), while no significant differences were observed in younger women (<38 years). Multivariate analysis, adjusting for parental age and body mass index (BMI), confirmed that AZ is an independent risk factor for reduced euploidy rates in the AMA subgroup. Notably, OZ and TZ cases showed no significant association with blastocyst ploidy rates. These results suggest that only in cases of advanced maternal age, impaired sperm motility adversely affect blastocyst euploidy rates.
Keywords: blastocyst; euploidy; preimplantation genetic testing for aneuploidy; sperm motility
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