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中文摘要

《亚洲男性学杂志》 2013; 15 (3): 342-349

转移性去势抵抗性前列腺癌的研究现状以及新颖的治疗措施
Paul J Toren and Martin E Gleave(加拿大)

去势抵抗前列腺癌的治疗方案近年来已经取得了很大的进展,让患有这种侵袭性致死性疾病的患者有了更多的希望。对这种疾病的生物学的进一步了解已经产生了几种新的靶向治疗方案,并且继续强调雄激素受体为主的治疗的重要性。治疗方案变化得很快,也更需要更多的生物学依据的基于生物标记物的临床试验。本文综述了主要的去势抵抗前列腺癌临床试验的最新结果。同时还综述了一些目前正在进行临床研究和评估的新药剂,包括肿瘤血管生成,微管,分子伴侣,AR和细胞外激酶的抑制剂和免疫治疗,放射性治疗和骨靶向药剂。最近去势抵抗前列腺癌预后研究的进展为将来的发展提供了希望。设计缜密的临床试验和治疗抵抗性机制的深入了解有助于进一步优化对去势抵抗前列腺癌患者的护理。

此摘要文献来源:
Paul J Toren and Martin E Gleave. Evolving landscape and novel treatments in metastatic castrate-resistant prostate cancer. Asian J Androl 2013;15: 342-349.

 
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