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中文摘要

《亚洲男性学杂志》 2013; 15 (3): 400-403

睾丸附件中抗缪勒管激素受体表达与泌尿疾病之间的联系
Kornél Kistamás, Olga Ruzsnavszky, Andrea Telek, Lívia Kosztka, Ilona Kovács, Beatrix Dienes, László Csernoch and Tamás Józsa(匈牙利,瑞典)

女性内部生殖器是由中肾旁的缪勒管发育而来的。在男性的胚胎中,缪勒管的退化是由抗缪勒管激素(AMH)引起的,其在睾丸下降的进程中起重要作用。睾丸附件(AT)是缪勒管的生理遗迹。在我们前面的研究中,我们呈现了隐睾症病人外科手术中降低AT发病率的一些证据。在这项研究中,我们研究了抗缪勒管激素受体亚型2在睾丸附件中的表达情况,查看其与不同的泌尿疾病之间的关联性,如腹股沟疝、睾丸附件扭转、附睾囊肿、精索静脉曲张、睾丸异位、睾丸收缩、睾丸保留、睾丸鞘膜积液等。同时也研究了病人年龄与抗缪勒管激素受体亚型2的表达之间的关系。用RT-PCR和免疫组化法分别检测mRNA受体和蛋白水平。我们证明了抗缪勒管激素受体亚型2在睾丸附件中有表达。此外,在mRNA和蛋白水平证实了受体的存在。受体表达模式既与被检测的泌尿疾病无关,也与病人的年龄无关。因此,AT的功能仍有待澄清。

关键词:抗苗勒氏管激素受体(AMHR),睾丸附件(AT), 腹股沟疝, 保留睾丸,睾丸下降,睾丸收缩

此摘要文献来源:
Kornél Kistamás, Olga Ruzsnavszky, Andrea Telek, Lívia Kosztka, Ilona Kovács et al. Expression of anti-Mullerian hormone receptor on the appendix testis in connection with urological disorders. Asian J Androl 2013;15: 400-403.

 
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