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中文摘要

《亚洲男性学杂志》 2013; 15 (3): 425-429

抗肿瘤治疗在睾丸肿瘤或者淋巴增殖性病变患者中对精液质量的影响
Cataldo Di Bisceglie, Angela Bertagna, Emanuela R Composto, Fabio Lanfranco, Matteo Baldi, Giovanna Motta, Anna M Barberis, Emanuela Napolitano, Elena Castellano and Chiara Manie(意大利)

对年轻男性的精液在抗癌治疗前进行低温冷冻保存,已经成为一项有利于癌症患者的临床实践指导方针。本文旨在概述不同的抗肿瘤治疗在睾丸肿瘤或者淋巴增殖性病变的病人中对精液质量的影响,研究是基于一家大型公立医院冷冻保存中心8年的经验报告。261名患有睾丸肿瘤和219名患有淋巴增殖性病变的患者,经历了化疗和放疗,并在治疗前对精液进行了低温冷冻保存。精子参数和一些激素参数(促卵泡激素(FSH), 促黄体激素(LH), 睾酮, 抑制素B的水平)都分别在抗癌治疗前,以及抗癌治疗结束后的第6,12,18,24和36个月进行评估。恶性睾丸肿瘤患者的FSH基线水平和精子浓度比淋巴增殖性病变患者有更大程度的削弱。精子发生的毒性效应在抗癌治疗结束的第6个月和12个月依然明显,抗癌治疗18个月后,精液参数明显改善。总之,尽管不可能去预测每一个单一病例的发展,大多数病人在抗癌治疗18个月后,精子浓度整体上增加了。基于这个原因,所有年轻的癌症患者都应考虑在抗癌治疗前做精液低温冷冻保存。

关键词:化疗放疗方法,淋巴增殖性病变,精液分析,精液冷冻保存 ,睾丸肿瘤

此摘要文献来源:
Cataldo Di Bisceglie, Angela Bertagna, Emanuela R Composto, Fabio Lanfranco, Matteo Baldi et al. Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders. Asian J Androl 2013;15: 425-429.

 
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