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中文摘要

《亚洲男性学杂志》 2011; 13 (5): 673-676

《亚洲男性学杂志》 2011; 13 (5): 673-676

前列腺癌中的瞬时受体电位通道:是善是恶还是丑?

Dimitra Gkika and Natalia Prevarskaya (法国)

近十年来,瞬时受体电位(TRP)通道逐渐成为细胞分化、细胞凋亡和细胞迁移等主要癌变机制中的关键蛋白。早期研究发现一些TRP 通道(具有代表性的有TRPM8 、TRPV6 、TRPC6 和TRPV2)的表达方式在前列腺癌向激素难治期发展的过程中也会发生改变。这些表达水平的改变与这些通道在前列腺癌中的功能之间的联系正在逐渐明晰。本文主要描述和讨论了这方面的最新进展。

关键词:激素非依赖性,离子通道,水解磷酸脂,迁移,神经内分泌,前列腺癌,前列腺特异抗原,TRPM8, TRPV6, TRPV2

 
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