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中文摘要

《亚洲男性学杂志》 2013; 15 (6): 790-794

《亚洲男性学杂志》 2013; 15 (6): 790–794

精子DNA完整性与形态超高倍检测在辅助生殖技术妊娠结局中的临床价值
Gemma López, Rafael Lafuente, Miguel A. Checa, Ramón Carreras and Mario Brassesco(西班牙)

近年来,涌现出许多重要的男性不育诊疗新技术。本研究旨在探讨精子DNA完整性与精子空泡率检测对以男性不育因素行IVF或ICSI治疗的不育症的治疗结局。本研究针对152对不育症夫妻行ART技术前进行的精子DNA碎片率与形态学超高倍分析进行队列研究。我们发现对妊娠结局最有预测价值的DNA碎片率切点值为25.5%,阴性预测值为72.7%(P=0.02)。在对空泡率的研究中发现,3、4级的空泡精子的最有预测价值切点值为73.5%,阴性预测值为39.4% (P=0.09),差异无统计学意义。总之,当精子DNA碎片率大于25%时,IVF失败的概率增大,而精子形态学超高倍检测结果对预测患者的妊娠结局无明显获益。

关键词:DNA 碎片率,超高倍检测,IVF, 空泡率

此摘要文献来源:
Gemma López, Rafael Lafuente, Miguel A. Checa, Ramón Carreras, Mario Brassesco. Diagnostic value of sperm DNA fragmentation and sperm high-magnification for predicting outcome of assisted reproduction treatment. Asian J Androl 2013;15: 790–794.

 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.