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中文摘要

《亚洲男性学杂志》 2014; 16 (3): 359-363

【特刊综述】前列腺癌中作为治疗靶点的热休克蛋白及其他凋亡相关蛋白

凋亡旁路的缺陷参与前列腺癌的发生、转移和耐药。癌症的一个特点就是能够通过抑制凋亡信号来干扰凋亡过程,通过增加抗凋亡分子减少凋亡蛋白的表达和/或增强残存信号的作用。本综述阐述热休克蛋白(HSPs)和人雄激素受体之间的关系,HSPs和其他应激蛋白在前列腺癌发展中的作用,以及以这些保护性蛋白为靶点的前列腺癌治疗新策略。

关键词:热休克蛋白,凋亡,凝聚素,bcl-2同源拮抗剂抑制蛋白,库司替森,Apatorsen, Ganetespib,前列腺癌

 
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