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中文摘要

《亚洲男性学杂志》 2014; 16 (5): 669-674

【观点】将表观遗传学引入男科实验室:挑战与前景
近期研究发现精子DNA甲基化的异常与自发性男性不育有
显著关联,自然流产及胚胎发育紊乱频发。因此,对精子中某些
特定基因DNA甲基化进行研究分析有可能成为临床男科中一种新
的有价值的诊断标记。本文讨论了DNA甲基化分析在男性不育症
诊断中的应用现状和价值,并且概述了面临的挑战和未来的应用
前景。本文突出介绍了DNA甲基化作用在男科诊断学的应用前
景,同时也对概述了其在自发性不育症的诊断价值。
关键词:DNA甲基化;男性不育症;精子发生
文献来源:Kläver R, Gromoll J. Bringing epigenetics into the
diagnostics of the andrology laboratory: challenges and perspectives.
Asian J Androl 2014; 16: 669–674

 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.