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中文摘要

《亚洲男性学杂志》 2015; 17 (1): 117-119

【原创论文】8q24I I区与瓜德罗普岛(法属西印度群岛)的
非洲裔加勒比男性前列腺癌进展的风险相关
基因组的多个区域,尤其是位于 8q24的多态性已被证实与白
种人的前列腺癌相关。8q24I I区已被发现与非洲裔男性前列腺
癌相关,但在加勒比岛牙买加进行的研究结果却没有重复这一
发现。对498例组织学证实的前列腺癌患者以及541例对照者,
检测位于8q24II区的rs16901979 的单核苷酸多态性,所有患者及
对照来自瓜德罗普岛的法属加勒比群岛非洲裔。rs16901979 的
AA基因型及A等位基因与前列腺癌风险升高有关(OR = 1.84,
95% CI= 1.26–2.69,P = 0.002; OR = 1.36,95% CI = 1.13–1.64,
P = 0.001)。将患者按照疾病侵袭性分型,即Gleason评分分型,
AC+AA基因型与高危Gleason评分相关 (OR = 1.79,95% CI =
1.17–2.73,P = 0.007)。总的来说,rs16901979的A等位基因与瓜
德罗普岛加勒比非洲裔男性前列腺癌的风险相关,也第一次证实
了这种变异与前列腺癌风险相关。
关键词:非洲大陆血统人群;侵袭性;加勒比地区;疾病遗传易
感性;前列腺癌
文献来源:Geraldine Cancel-Tassin, Marc Romana, Cecile Gaffory,
Pascal Blanchet, Olivier Cussenot, et al. Region 2 of 8q24 is
associated with the risk of aggressive prostate cancer in Caribbean
men of African descent from Guadeloupe (French West Indies). .Asian
J Androl 2015; 17: 117–9

 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.