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中文摘要

《亚洲男性学杂志》 2015; 17 (6): 991-995

我们采用多中心、横断面研究方法探讨了3332例中国成年男性血清睾酮水平及性激素结合球蛋白(SHBG)水平与代谢综合征之间的关系。本研究中代谢综合征的患病率为34.7%, 代谢综合征组血清总睾酮水平与SHBG水平明显低于正常对照组(P < 0.001),而血清游离睾酮水平在两组中无明显差异(P = 0.627)。logistic回归分析中调整年龄、体质指数(BMI)、抽烟饮酒和总睾酮的影响因素后,SHBG仍然是代谢综合征的主要危险因素(OR = 0.962, 95% CI = 0.954–0.969, P < 0.01),而当调整年龄、BMI、抽烟饮酒和SHBG的影响因素后,血清总睾酮水平与代谢综合征无关(OR = 0.981, 95% CI = 0.960–1.007)。我们认为代谢综合征的发生与血清总睾酮和SHBG水平有关,而与游离睾酮水平无关。SHBG是代谢综合征的独立的主要危险因素。
关键词:代谢综合征;性激素结合球蛋白;睾酮

 
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