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中文摘要

《亚洲男性学杂志》 2009; 11 (1): 36-38

《亚洲男性学杂志》 2009; 11 (1): 36-38

【综述】小类泛素修饰蛋白特异的蛋白酶1和前列腺癌

Yong Zuo, Jin-Ke Cheng(中国)

小类泛素修饰蛋白(SUMO)修饰是一个高度动态的过程,该过程经SUMO特异性 E1、E2和E3酶催化,可由SUMO特异性蛋白酶(SENPs)逆转。人类SENP家族中有6个成员,每个SENP的细胞分布和底物特异性不同。然而,SENPs在细胞过程中的确切作用至今还不清楚。本文综述了以被证实的SENP1靶向的最新进展及其在前列腺癌中的潜在作用。

关键词:小类泛素修饰蛋白,小类泛素修饰蛋白特异蛋白酶,前列腺癌,雄激素受体,HIF1

 
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