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中文摘要

《亚洲男性学杂志》 2008; 10 (1): 14-22

《亚洲男科学杂志》 2008; 10(1): 14-22

【综述】基于内皮细胞特异性基因和干细胞的勃起功能障碍疗法

Travis D. Strong, Milena A. Gebska, Arthur L. Burnett, Hunter C. Champion, Trinity J. Bivalacqua(美国)

勃起功能障碍(ED)通常起因于体循环血管中血管内皮功能障碍。虽然PDE-5抑制剂在大多数情况下能有效地治疗ED,但是它必须长期服用,并对相当一部分人是无效的。近些年来,针对阴茎内皮细胞的基因和干细胞疗法的临床前研究势头越来越大。这些早期研究表明基于基因和干细胞的疗法是持久和有效的,并有可能根治ED。此篇综述将重点讨论目前对在一些试验动物模型中进行内皮细胞特异性基因和干细胞为基础的ED疗法的了解。

关键词:勃起功能障碍;内皮细胞特异基因;内皮功能障碍;基因治疗

 
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