Fei Sun

Academic Record
Undergraduate
Bachelor of Medicine in Clinical Medicine, 1994, Xuzhou Medical College, China
Graduate
MSc in Obstetrics & Gynecology, 1997, Qingdao University, China
PhD, MD in Obstetrics & Gynecology, 2000, Fudan University, Shanghai, China

Postdoctoral Fellowships
Molecular mechanisms of mammalian sperm chemotaxis
Supervisor: Dr. Michael Eisenbach, Weizmann Institute of Science, Rehovot, Israel, 2000 - 2002.
Collaborative project: Measuring species - specificity of mammalian sperm chemotaxis
Supervisor: Dr. Laura C. Giojalas, National University of Córdoba, Argentina, 2001.
Molecular mechanisms of human meiotic recombination abnormalities
Supervisor: Dr. Renée H. Martin, University of Calgary, Canada, 2002 - 2006.
Collaborative project: Defective recombination in infertile men
Supervisor: Dr. Renee A. Reijo Pera, University of California at San Francisco, USA, 2003

Academic Appointments
2006 – 2004: Professor, University of Science and Technology of China
2004 – Present: Professor, Shanghai Jiaotong University

Awards and Distinctions
Chinese Association of Integrated Medicine Best Research Paper 2000
Shanghai Science & Technology Progress Silver Medal 2001
Sir Charles Clore Postdoctoral Fellowship 2001 – 2003
Canadian Institute of Health Research (CIHR) Training Program Travel Award 2003, 2004
Canadian Fertility and Andrology Society Best Basic Science Research Paper 2004
CIHR Strategic Training Program Fellowship in Genetics 2003 - 2005
100-Talent Programme, Chinese Academy of Sciences, 2006-2011
Young Faculty Career Award, USTC Alumni Foundation 2007
Chief scientist of National 973 program, 2009-2013
France Talent Innovation Laureate 2010
Le programme Xu Guangqi 2011
National Science Foundation for Distinguished Young Scholars, 2012-2015

Professional Activities
Membership in Professional and Learned Societies
American Society of Human Genetics
Chinese Society of Cell Biology
Chinese Society of Genetics
Chinese Society of Integrated Medicine
China Zoological Society
Professional Service
2007-present: Member of Editorial Board, Journal of Reproductive Medicine
2007-present: Standing Committee, Chinese Society of Integrated Medicine
2009-present: Standing Committee, Branch of Reproductive Biology, China Zoological Society
2012-present: Associate Editor, Molecular Human Reproduction

Publications

1. Sun F, Yan DQ, Zhang CL, Yu J, Xiao EN. Miscarriage Prevention Tea affects plasma ß- endorphin concentrations in women with early threatened abortions. Am J Chin Med, 1999, 27(2):277-282.
2. Sun F, Yu J. The effect of a special herbal tea on obesity and anovulation in androgen-sterilized rats. Proc Soc Exp Biol Med, 2000, 223(3):295-301.
3. Sun F, Giojalas LC, Rovasio RA, Tur-Kaspa I, Sanchez R, Eisenbach M. Lack of species- specificity in mammalian sperm chemotaxis. Dev Biol, 2003, 255(2):423-427.
4. Sun F, Kozak G, Scott S, Trpkov K, Ko E, Mikhaail-Philips M, Bestor TH, Moens P, Martin RH. Meiotic defects in a man with non-obstructive azoospermia: Case report. Hum Reprod, 2004, 19(8):1770-1773. Selected for cover illustration.
5. Sun F, Trpkov K, Rademaker A, Ko E, Barclay L, Mikhaail-Philips M, Martin RH. The effect of cold storage on recombination frequencies in human male testicular cells. Cytogenet Genome Res, 2004, 106(1):39-42.
6. Sun F, Oliver-Bonet M, Liehr T, Starke H, Ko E, Rademaker A, Navarro J, Benet J, Martin RH. Human male recombination maps for individual chromosomes. Am J Hum Genet, 2004 Mar;74(3):521-531.
7. Sun F, Bahat A, Gakamsky A, Girsh E, Katz N, Giojalas LC, Tur-Kaspa I, Eisenbach M. Human sperm chemotaxis: both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants. Hum Reprod, 2005, 20(3):761-767.
8. Sun F, Trpkov K, Rademaker A, Ko E, Martin RH. Variation in meiotic recombination frequencies among human males. Hum Genet, 2005, 116(3):172-178.
9. Sun F, Oliver-Bonet M, Turek PJ, Ko E, Martin RH. Meiotic study on (Y; 1) translocation in a male with azoospermia. Mol Hum Reprod, 2005, 11(5):361-364. Selected for cover illustration.
10. Sun F, Greene C, Turek PJ, Ko E, Rademaker A, Martin RH. Immunofluorescent synaptonemal complex analysis in azoospermic men. Cytogenet Genome Res, 2005, 111(3-4):366-370.
11. Sun F, Oliver-Bonet M, Liehr T, Starke H, Trpkov K, Ko E, Rademaker A, Martin RH. Discontinuous and unpaired regions in meiotic chromosome have a cis effect on meiotic recombination patterns in normal human males. Hum Mol Genet, 2005, 14(20):3013-3018.
12. Sun F, Ko E, Martin RH. Is there a relationship between sperm chromosome abnormalities and sperm morphology? Reprod Biol Endocrinol, 2006, 4:1.
13. Sun F, Oliver-Bonet M, Liehr T, Starke H, Turek P, Ko E, Rademaker A, Martin RH. Variation in MLH1 distribution in recombination maps for individual chromosomes from human males. Hum Mol Genet, 2006, 15(15):2376-2391. Selected for cover illustration.
14. Sun F, Oliver-Bonet M, Liehr T, Starke H, Turek P, Ko E, Rademaker A, Martin RH. Analysis of non-crossover bivalents in pachytene cells from 10 normal men. Hum Reprod, 2006, 21(9):2335-2339. Selected for cover illustration.
15. Sun F, Turek P, Ko E, Rademaker A, Martin RH. Abnormal progression through meiosis in men with nonobstructive azoospermia. Fertil Steril, 2007, 87(3):565-571. Selected for cover illustration.
16. Sun F, Oliver-Bonet M, Liehr T, Starke H, Ko E, Rademaker A, Martin RH. Discontinuities and unsynapsed regions in meiotic chromosomes have a trans effect on meiotic recombination of some chromosomes in human males. Cytogenet Genome Res, 2007, 119(1-2):27-32.
17. Sun F, Mikhaail-Philips M, Oliver-Bonet M, Ko E, Rademaker A, Turek P, Martin RH. The relationship between meiotic recombination in human spermatocytes and aneuploidy in sperm. Hum Reprod, 2008, 23(8):1691-1697. Selected for cover illustration.
18. Sun F, Mikhaail-Philips M, Oliver-Bonet M, Ko E, Rademaker A, Turek P, Martin RH. Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with non-obstructive azoospermia. Mol Hum Reprod, 2008, 14(7):399-404. Selected for cover illustration.
19. Lian J, Yin YM, Oliver-Bonet M, Liehr T, Ko E, Turek P, Sun F, Martin RH. Variation in crossover interference levels on individual chromosomes from human males. Hum Mol Genet, 2008, 17(17):2583-2594. Selected for cover illustration.
20. Lian J, Zhang XS, Tian H, Liang N, Wang Y, Liang CZ, Li X, Sun F. Altered microRNA expression in patients with non-obstructive azoospermia. Reprod Biol Endocrinol, 2009, 7:13.
21. Tang M, Li Z, Chen L, Xing T, Hu Y, Yang B, Ruan DY, Sun F, Wang M. The effect of quantum dots on synaptic transmission and plasticity in the hippocampal dentate gyrus area of anesthetized rats. Biomaterials, 2009, 30(28):4948-4955.
22. Yao GD, Yin MM, Lian J, Tian H, Liu L, Li X, Sun F. MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cel1 proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol, 2010, 24(3): 540-551.
23. Lian J, Tian H, Liu L, Zhang XS, Li WQ, Deng YM, Yao GD, Yin MM, Sun F. Down-regulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. Cell Death Dis, 2010, 1, e94; Highlighted in Cell Death Dis.
24. Liang N, Xu YL, Yin YM, Yao GD, Tian H, Wang GS, Lian J, Wang Y, and Sun F. Steroidogenic Factor-1 Is Required for TGF-β3-Mediated 17β-Estradiol Synthesis in Mouse Ovarian Granulosa Cells. Endocrinology 2011 Aug;152(8):3213-25. Editor's Choice
25. Yin M, Lü M, Yao G, Tian H, Lian J, Liu L, Liang M, Wang Y, Sun F. Transactivation of microRNA-383 by Steroidogenic Factor-1 Promotes Estradiol Release from Mouse Ovarian Granulosa Cells by Targeting RBMS1. Mol Endocrinol. 2012 Jul;26(7):1129-43.
26. Li WQ, Wang F, Liu ZM, Wang YC, Wang J, Sun F. Gold Nanoparticles Elevate Plasma Testosterone Levels in Male Mice without Affecting Fertility. Small 2013, 9(9-10):1708-14.
27. Zhimin Liu, Wenqing Li, Feng Wang, Chunyang Sun, Lu Wang, Jun Wang and Fei Sun. Enhancement of lipopolysaccharide-induced nitric oxide and interleukin-6 production by PEGylated gold nanoparticles in RAW264.7 cells. Nanoscale, 2012, 4(22):7135-7142.
28. Yimeng Yin, Guishuan Wang, Ning Liang, Huijuan Zhang, Zhimin Liu, Wenqing Li and Fei Sun. Nuclear Export Factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells. Biochem J 2013, 452(1):67-78.
29. Liang M, Yao G, Yin M, Lü M, Tian H, Liu L, Lian J, Huang X, Sun F. Transcriptional cooperation between p53 and NF-κB p65 regulates microRNA-224 transcription in mouse ovarian granulosa cells. Mol Cell Endocrinol 2013, 370(1-2):119-129.
30. Liu L, Lian J, Zhang H, Tian H, Liang M, Yin M, Sun F. MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. J Cell Physiol. 2013, 228(12):2294–2304.
31. Tian H, Cao YX, Zhang XS, Liao WP, Yi YH, Lian J, Liu L, Huang HL, Liu WJ, Yin MM, Liang M, Shan G, Sun F. The targeting and functions of miRNA-383 are mediated by FMRP during spermatogenesis. Cell Death Dis. 2013 May 2;4:e617.
32. Li WQ, Sun C, Wang F, Wang YC, Zhai YW, Liang M, Liu WJ, Liu ZM, Wang J, Sun F. A chieving a new controllable male contraception by photothermal effect of gold nanorods. Nano Lett 2013, 13 (6):2477–2484. Comments on: Nature Matertials 2013,12(7):602: Nano contraception；Chemistry World: Will nanorods be the next big male contraceptive idea? ；Chemistry & Engineering News: Reversible Male Contraception With Gold Nanorods.
33. Yao G, Liang M, Liang N, Yin M, Lü M, Lian J, Wang Y, Sun F. MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3. Mol Cell Endocrinol 2014, 382(1):244-253.
34. Wang Y, Liang N, Yao G, Tian H, Zhai YW, Yin YM, Sun F. Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6. Mol Cell Endocrinol 2014, 382(2):804-813.
35. Huang H, Tian H, Duan Z, Cao Y, Zhang XS, Sun F. microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. Cell Signal 2014, 26(5):903-911
36. Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep 2014, 4:4260.
37. Liu W, Wang L, Zhao W, Song G, Xu R, Wang G, Wang F, Li W, Lian J, Tian H, Wang X, Sun F. Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice. Dev Biol 2014, 392(1):108-116.
38. Wang L, Liu W, Zhao W, Song G, Wang G, Wang X, Sun F. Phosphorylation of CDK2 on Threonine 160 Influences Silencing of Sex Chromosome During Male Meiosis. Biol Reprod 2014, 90(6):1381-1387.
39. Yin M, Wang X, Yao G, Lü M, Liang M, Sun Y, Sun F. Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins. J Biol Chem 2014, 289 (26):18239-18257.
40. Liang M, Li WQ, Tian H, Hu T, Wang L, Lin Y, Li YL, Huang HF, Sun F. Sequential expression of long noncoding RNA as mRNA gene expression in specific stages of mouse spermatogenesis. Sci Rep 2014 Aug 6;4:5966.