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Volume 15, Issue 2 (March 2013) 15, 241–245; 10.1038/aja.2012.120
Perioperative complications of radical retropubic prostatectomy in patients with locally advanced prostate cancer: a comparison with clinically localized prostate cancer
Xu-Dong Yao1,*, Xiao-Jun Liu2,*, Shi-Lin Zhang1, Bo Dai1, Hai-Liang Zhang1 and Ding-Wei Ye1
1 Department of Urology, Cancer Hospital, Fudan University, Shanghai 200032, China
2 Shanghai Medical College, Fudan University, Shanghai 200032, China
* These two authors contributed equally to this work.
Correspondence: Professor DW Ye, (dwye@shca.org.cn)
Received 14 June 2012; Revised 8 August 2012; Accepted 24 September 2012
| Abstract |
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Radical prostatectomy (RP) continues to be an effective surgical therapy for prostate carcinoma, particularly for organ-confined prostate cancer (PCa). Recently, RP has also been used in the treatment of locally advanced prostate cancer. However, little research has been performed to elucidate the perioperative complications associated with RP in patients with clinically localized or locally advanced PCa. We sought to analyse the incidence of complications in these two groups after radical retropubic prostatectomy (RRP). From June 2002 to July 2010, we reviewed 379 PCa patients who underwent RRP in our hospital. Among these cases, 196 had clinically localized PCa (T1a–T2c: group 1), and 183 had locally advanced PCa (≥T3a: group 2). The overall complication incidence was 21.9%, which was lower than other studies have reported. Perioperative complications in patients with locally advanced PCa mirror those in patients with clinically localized PCa (26.2% vs. 17.8%, P=0.91). Our results showed that perioperative complications could not be regarded as a factor to consider in regarding RP in patients with cT3 or greater.
Keywords: complications; clinically localized prostate cancer; locally advanced prostate cancer; prostate cancer (PCa); prostatectomy; radical retropubic prostatectomy (RRP)
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