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Volume 15, Issue 4 (July 2013) 15, 564–566; 10.1038/aja.2013.34
Trabecular bone deterioration at the greater trochanter of mice with unilateral obstructive nephropathy
Sa-Sa Gu1, Yan Zhang1,2,3, Xi Chen2, Teng-Yue Diao2, Yoseph Gebru2 and Man-Sau Wong3
1 Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China
2 School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
3 Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China
Correspondence: Dr Y Zhang, (medicineyan@usst.edu.cn)
Received 10 December 2012; Revised 31 January 2013; Accepted 20 March 2013; Advance online publication 6 May 2013
| Abstract |
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Our previous study showed the early molecular responses of bone in response to obstructive nephropathy in a unilateral ureteral obstruction (UUO) mouse model. Here, we addressed the changes in trabecular bone properties at greater trochanter, the proximal and the distal metaphysis of femur in UUO mice. The male mice were subjected to UUO (n=10) or sham operation (n=10). All mice were killed on day 7 after the surgical operation. The micro-computed tomography (micro-CT) analysis for different femoral trabecular bone sites demonstrated pathological alterations of trabecular bone mass and micro-networks at greater trochanter as shown by decreases in bone mineral density/bone volume (P<0.05) and trabecular number (P<0.05) and increases in trabecular separation (P<0.01) and bone surface/bone volume (P<0.05) in UUO mice. The present study demonstrates that UUO-induced unilateral obstructive nephropathy has markedly detrimental effects on the trabecular trochanter of the femur.
Keywords: bone; femur; micro-computed tomography (micro-CT); trochanter; unilateral ureteral obstruction (UUO)
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