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Abstract

Volume 11, Issue 1 (January 2009) 11, 36–38; 10.1038/aja.2008.45

Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer

Yong Zuo and Jin-Ke Cheng

Laboratory for Cell Signal Transduction, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Correspondence: Dr Jin-Ke Cheng, Laboratory for Cell Signal Transduction, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Fax: +86-21-6466-1525 E-mail: jkcheng@shsmu.edu.cn

Received 9 November 2008; Accepted 10 November 2008; Published online 22 December 2008

Abstract

Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). There are six members of the human SENP family, and each SENP has different cellular locations and substrate specificities. However, the precise roles of SENPs in cellular processes have not been elucidated to date. This brief review will focus on recent advances pertaining to the identified targets of SENP1 and its potential role in prostate cancer.

Keywords: SUMO, SUMO-specific protease, prostate cancer, androgen receptor, HIF1

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