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Volume 13, Issue 4 (July 2011) 13, 640–643; 10.1038/aja.2010.104

Body mass index and serum lipid profile influence serum prostate-specific antigen in Chinese men younger than 50 years of age

Ming Liu1, Jian-Ye Wang1, Ling Zhu2 and Gang Wan3

1 Department of Urology, Beijing Hospital, No. 1 Dahua Road, Dongcheng District, Beijing 100730, China
2 Health Assessment Center, Beijing Hospital, NO.1 Dahua Road, Dongcheng District, Beijing 100730, China
3 Medical Statistics Department, Ditan Hospital, No. 13, Ditan Street, Dongcheng District, Beijing 100015, China

Correspondence: Dr JY Wang, (wangjy@bjhmoh.cn)


This study is to assess the potential factors that could affect the serum prostate-specific antigen (PSA) level in healthy younger men. We evaluated the associations of age, body mass index (BMI) and serum lipid profile with serum PSA level in 6774 Chinese men (aged 20-49 years) who received a routine health examination. Eligible men were classified into 10-year age groups. BMI was categorized as underweight (<18.5), normal (18.5-22.9), overweight (23.0-24.9), obese (25.0-29.9) and very obese (>30) according to the redefined World Health Organization (WHO) criteria for the Asia-Pacific region. PSA levels were compared among groups as well. In multiple linear regression analysis, PSA was positively correlated with age (P<0.0001). Negative correlations existed between PSA and BMI (P<0.0001) and triglyceride level (P=0.01). No relationship could be found between PSA and serum cholesterol (P=0.711) or high-density lipoprotein (HDL; P =0.665). In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men <50 years of age.

Keywords: age; body mass index; prostate-specific antigen; serum lipid profile

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