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Abstract

Volume 13, Issue 4 (July 2011) 13, 550–557; 10.1038/aja.2010.130

Current therapeutic strategies for premature ejaculation and future perspectives

Zhong-Cheng Xin1, Yi-Chen Zhu2, Yi-Ming Yuan1, Wan-Shou Cui1, Zhe Jin1, Wei-Ren Li1 and Tao Liu1

1 Andrology Centre of Peking University First Hospital, Peking University, Beijing 100034, China
2 Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Correspondence: Professor ZC Xin, ((xinzc@bjmu.edu.cn), (xinzc08@gmail.com))

Abstract

Premature ejaculation (PE) is a common sexual disorder in men that is mediated by disturbances in the peripheral and central nervous systems. Although all pharmaceutical treatments for PE are currently used 'off-label', some novel oral agents and some newer methods of drug administration now provide important relief to PE patients. However, the aetiology of this condition has still not been unified, primarily because of the lack of a standard animal model for basic research and the absence of a widely accepted definition and assessment tool for evidence-based clinical studies in patients with PE. In this review, we focus on the current therapeutic strategies and future treatment perspectives for PE.


Keywords: 5-HT; dapoxetine; premature ejaculation; sexual disorder; selective serotonin reuptake inhibitor; treatment

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