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Volume 15, Issue 2 (March 2013) 15, 214–215; 10.1038/aja.2012.150
Hidden gems in the niche: a new approach to the study of spermatogonial stem cells
Kate L Loveland1 and Eileen A McLaughlin2
1 NHMRC Senior Research Fellow Building 77, School of Biomedical Sciences, Monash University, Clayton, VIC 3800, Australia
2 Priority Research Centres in Chemical Biology and Reproductive Science, School of Environmental & Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
Correspondence: Dr KL Loveland, (kate.loveland@monash.edu)
published online 14 January 2013
| Abstract |
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Kanatsu-Shinohara and colleagues continue to reveal the secrets of the rare mammalian spermatogonial stem cells. Their most recent study offers a new approach by applying principles from hematopoietic stem cell research to demonstrate that cells which form a cobblestone-like underlay beneath testicular somatic cells in culture are spermatogonial stem cells. Utilization of mouse models and cell cultures shows how the chemokine, CXCL12, fits into the signalling cascade which governs the fate of these cells and hence is essential to male fertility.
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