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Abstract

Volume 15, Issue 3 (May 2013) 15, 409–412; 10.1038/aja.2013.11

Prostate volume as an independent predictor of prostate cancer in men with PSA of 10–50 ng ml−1

Ping Tang1, Xiao-Long Jin2, Matthew Uhlman3, Yu-Rong Lin1, Xiang-Rong Deng1, Bin Wang1 and Ke-Ji Xie1

1 Department of Urology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China
2 Postgraduate Institute, Southern Medical University, Guangzhou 510515, China
3 Department of Urology, University of Iowa, Iowa City, IA 52242, USA

Correspondence: Dr KJ Xie, (xiekeji@sina.com)

Received 22 November 2012; Revised 19 December 2012; Accepted 20 January 2013 Advance online publication 8 April 2013

Abstract

Prostate volume (PV) has been shown to be associated with prostate cancer (PCa) detection rates in men with a prostate-specific antigen (PSA) in the ‘grey zone’ (2.0–10.0 ng ml−1). However, the PSA ‘grey zone’ in Asian men should be higher because the incidence of PCa in Asian men is relatively low. Therefore, we evaluated the association between PV and PCa detection rates in men with PSAs measuring 10–50 ng ml−1. Men who underwent a 13-core prostatic biopsy with PV documentation participated in the study. A multivariate stepwise regression was used to evaluate whether the PV at time of prostate biopsy could predict the risk of PCa. The rates of PCa among men in different PSA ranges, stratified by PV medians (<60 and ≥60 ml), were calculated. There were 261 men included in the final analysis. PV was the strongest predictor of PCa risk (odds ratio, 0.02; P<0.001) compared to other variables. The PCa rates in men with PVs measuring <60 and ≥60 ml in the 10–19.9 ng ml−1 PSA group were 40.6% and 15.1%, respectively, while the rates for men with PSAs measuring 20–50 ng ml−1 were 65.1% and 26.8%. PV is an independent predictor of PCa in men with PSA measuring 10–50 ng ml−1. In clinical practice, particularly for those countries with lower incidences of PCa, PV should be considered when counselling patients with PSAs measuring 10–50 ng ml−1 regarding their PCa risks.


keywords: prostate biopsy; prostate cancer (PCa); prostate-specific antigen (PSA); prostate volume (PV)

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