|
Volume 7, Issue 2 (March 2005) 7, 115–120; 10.1111/j.1745-7262.2005.00048.x
RNA in human sperm
Rui Pires Martins and Stephen A Krawetz
1.Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA
2.Department of Obstetrics and Gynecology, Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA
3.Institute for Scientific Computing, Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201, USA
Received: 2005-01-17 Accepted: 2005-04-11
| Abstract |
|
We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa. This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in preparation for their delivery to the egg. The diversity of these transcripts is vast, including several anti-sense molecules resembling known regulatory micro-RNAs. The field is still grasping with its delivery to the oocyte at fertilization and possible significance. It remains tempting to analogize them to maternally-derived transcripts active in early embryo patterning. Irrespective of their role in the embryo, their use as a means to assess male factor infertility is promising.
Keywords: RNA, siRNA, miRNA, sperm, microarray, fertilization, diagnostics
Full Text |
PDF |
|
| |
| Browse: 5426 |
|
