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Volume 10, Issue 1 (January 2008) 10, 6–13; 10.1111/j.1745-7262.2008.00371.x
NADPH oxidase: recent evidence for its role in erectile dysfunction
Liming Jin and Arthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Correspondence: Dr. Liming Jin, Department of Internal Medicine, University of California, Davis, CA 95616, USA. Fax: +1-530-752-3470. E-mail: lmjin@ucdavis.edu
| Abstract |
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Important roles for reactive oxygen species (ROS) in physiology and pathophysiology have been increasingly recognized. Under normal conditions, ROS serve as signaling molecules in the regulation of cellular functions. However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributes significantly to the pathogeneses of vascular diseases. Although it has become evident that increased ROS is associated with erectile dysfunction (ED), the sources of ROS in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH oxidase in inducing ED. In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derived ROS in ED.
Keywords: reactive oxygen species, erectile function, superoxide, penis, nitric oxide
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