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Volume 16, Issue 5 (September 2014) 16, 669–674; 10.4103/1008-682X.125412
Bringing epigenetics into the diagnostics of the andrology laboratory: challenges and perspectives
Ruth Kläver, Jörg Gromoll
Centre of Reproductive Medicine and Andrology, University Clinics of Münster, Münster 48149, Germany.
Correspondence: Prof. J Gromoll (Joerg.Gromoll@ukmuenster.de)
Date of Submission 24-Sep-2013 Date of Decision 11-Nov-2013 Date of Acceptance 04-Dec-2013 Date of Web Publication 30-May-2014
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Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspectives article discusses the current state and value of DNA methylation analysis in the diagnostic setup of infertile men and outlines challenges and perspectives. It highlights the potential of DNA methylation in andrological diagnostics and its putative benefit in the examination of hitherto idiopathic infertile patients is described.
Keywords: DNA methylation; male infertility; spermatogenesis
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