Home  |   Archive  |   Online Submission  |   News & Events  |   Subscribe  |   APFA  |   Society  |   Contact Us  |   中文版
Search   
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

 
Abstract

Volume 16, Issue 3 (May 2014) 16, 354–358; 10.4103/1008-682X.125392

Glucocorticoids and prostate cancer treatment: friend or foe?

Bruce Montgomery1 Heather H. Cheng1 James Drechsler2 Elahe A. Mostaghel1,3

1Department of Medicine, University of Washington,
2Seattle Cancer Care Alliance,
3Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle WA, USA

Correspondence: Dr. B Montgomery (rbmontgo@uw.edu)

Received: 29 October 2013; Revised: 26 December 2013; Accepted: 27 December 2013

Abstract

Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control, and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors. In this review we examine historical and contemporary use of glucocorticoids in the treatment of prostate cancer, review potential mechanisms by which they may inhibit or drive prostate cancer growth, and describe potential means of defining their contribution to the biology of prostate cancer.

Keywords: androgen receptor; dihydrotestosterone; glucocorticoid receptor; glucocorticoids; prostate cancer; steroids; testosterone

Full Text | PDF | 中文摘要 |

 
Browse:  2219
 
Copyright 1999-2017  Shanghai Materia Medica, Shanghai Jiao Tong University.  All rights reserved