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Abstract

Volume 16, Issue 4 (July 2014) 16, 549–554; 10.4103/1008-682X.129211

Current early diagnostic biomarkers of prostate cancer

Min Qu, Shan-Cheng Ren, Ying-Hao Sun

Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China

Correspondence: Prof. YH Sun (sunyh@medmail.com.cn)

Received: 03 December 2013; Revised: 25 February 2014; Accepted: 11 March 2014 INVITED REVIEW Prostate Cancer Open Access

Abstract

Prostate cancer (PCa) has become to have the highest incidence and the second mortality rate in western countries, affecting men's health to a large extent. Although prostate-specific antigen (PSA) was discovered to help diagnose the cancer in an early stage for decades, its specificity is relative low, resulting in unnecessary biopsy for healthy people and over-treatment for patients. Thus, it is imperative to identify more and more effective biomarkers for early diagnosis of PCa in order to distinguish patients from healthy populations, which helps guide an early treatment to lower disease-related mortality by noninvasive or minimal invasive approaches. This review generally describes the current early diagnostic biomarkers of PCa in addition to PSA and summarizes the advantages and disadvantages of these biomarkers.

Keywords: early diagnostic biomarkers; MALAT1-derived miniRNA; PCA3; prostate cancer; PSA

Full Text | PDF | 中文摘要 |

 
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