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Volume 17, Issue 6 (November 2015) 17, 942–947; 10.4103/1008-682X.150253

Peroxisome proliferator‑activated receptor gamma signaling in human sperm physiology

Li‑Li Liu1,2, Hua Xian2, Jing‑Chen Cao1, Chong Zhang1, Yong‑Hui Zhang1, Miao‑Miao Chen1, Yi Qian1,2, Ming Jiang1,3

1Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China; 2Department of Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China; 3Division of Epidemiology, Department of Medicine, Vanderbilt‑Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Correspondence: Correspondence: Prof. M Jiang (ming.jiang@ntu.edu.cn; ming.jiang@vanderbilt.edu)



Peroxisome proliferator‑activated receptor gamma (PPAR) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPAR acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic‑pituitary‑gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPAR protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPAR signaling in regulating sperm energy dissipation. PPAR protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini‑review will focus on how PPAR signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.

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