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Abstract

Volume 17, Issue 6 (November 2015) 17, 878–881; 10.4103/1008-682X.150841

Testosterone replacement therapy and the risk of prostate cancer

Daniel Warburton, Christopher Hobaugh, Grace Wang, Haocheng Lin, Run Wang

1 Division of Urology, University of Texas Medical School at Houston, Department of Urology, Houston, Texas, USA
2 Division of Urology, University of Texas Medical School at Houston, Department of Urology; University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA

Correspondence: Prof. R Wang (run.wang@uth.tmc.edu)

2015-04-10

Abstract

Understanding the role of testosterone replacement therapy (TRT) in the development and progression of prostate cancer is an important concept in treating patients with symptoms of hypogonadism. This article revealed a small number of mostly retrospective, observational studies describing the use of TRT in the general population, in men with prostatic intraepithelial neoplasia (PIN), in men with a history of treated prostate cancer, and in men on active surveillance for prostate cancer. The current literature does not report a statistically significant increase in the development or progression of prostate cancer in men receiving testosterone replacement for symptomatic hypogonadism, and the prostate saturation theory provides a model explaining the basis for these results. The use of TRT in men with a history of prostate cancer is considered experimental, but future results from randomized controlled trials could lead to a change in our current treatment approach.

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