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Volume 17, Issue 5 (September 2015) 17, 742–748; 10.4103/1008-682X.155536

Posttesticular sperm maturation, infertility, and hypercholesterolemia

Marjorie Whitfield, Xavier Pollet-Villard, Rachel Levy, Joël R Drevet, Fabrice Saez

1Team “Mechanisms of post‑testicular infertility”, Génétique Reproduction et Développement, UMR CNRS 6293 ,  INSERM U1103, Clermont Université ,  24 Avenue des Landais, BP80026, 63171 Aubière Cedex, France; 2Service d’Histologie‑Embryologie‑Cytogénétique‑CECOS, Hôpital Jean Verdier (AP‑HP), Avenue du 14 Juillet, 93143 Bondy, France; 3Service de Médecine de la Reproduction, Hôpital Tenon (AP‑HP), 4 Rue de la Chine, 75020, Paris, France; 4Unité de Recherche en Epidémiologie Nutritionnelle, INSERM U557, INRA, CNAM , Université Paris 13, CRNH IdF, 93017 Bobigny, France.

Correspondence: Prof. JR Drevet (joel.drevet@univ‑bpclermont.fr)



Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia) affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa.

Keywords: cholesterol; dyslipidemia; epididymis; fertility; posttesticular maturation; spermatozoa

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.