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Abstract

Volume 17, Issue 5 (September 2015) 17, 749–755; 10.4103/1008-682X.155540

Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice

Aki Murashima, Bingfang Xu, Barry T Hinton

Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Wakayama, Japan
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA

Correspondence: Prof. Barry T Hinton

26-Jun-2015

Abstract

The development of the Wolffian/epididymal duct is crucial for proper function and, therefore, male fertility. The development of the epididymis is complex; the initial stages form as a transient embryonic kidney; then the mesonephros is formed, which in turn undergoes extensive morphogenesis under the influence of androgens and growth factors. Thus, understanding of its full development requires a wide and multidisciplinary view. This review focuses on mouse models that display abnormalities of the Wolffian duct and mesonephric development, the importance of these mouse models toward understanding male reproductive tract development, and how these models contribute to our understanding of clinical abnormalities in humans such as congenital anomalies of the kidney and urinary tract (CAKUT).

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.