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Volume 17, Issue 5 (September 2015) 17, 708–710; 10.4103/1008-682X.156119
Phosphorylation of Izumo1 and Its Role in Male Infertility
Samantha A. M. Young, John Aitken, Mark A. Baker
1Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, NSW, Australia; Animal Resource Centre for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan,
2 Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, NSW, Australia,
Correspondence: Dr.MA Baker(mark.baker@newcastle.edu.au)
18 May 2015
| Abstract |
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Izumo1 is a testis-specific gene product, whose function is essential for sperm-egg fusion. Throughout its lifespan, Izumo1 is posttranslationally modified, being both N-linked glycosylated on its extracellular domain and phosphorylated on the intracellular C-terminal tail. Within the caput regions of the rat epididymis, two phosphorylation events have been documented. However, as sperm pass through the epididymis, this cytoplasmic portion of Izumo1 has been shown to contain up to seven phosphorylation sites. Remarkably, in the rat, in correlation with these events, Izumo1 undergoes sub-cellular re-location, moving from the head/tail regions of the spermatozoa, to a predominantly equatorial segment location once they have reached the caudal end of the epididymis.
Keywords: epididymis; Izumo1; LC-MS; phosphorylation; proteomics
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