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Volume 20, Issue 5 (September 2018) 20, 465–472; 10.4103/aja.aja_16_18

Combination of stromal vascular fraction and Ad-COMP-Ang1 gene therapy improves long-term therapeutic efficacy for diabetes-induced erectile dysfunction

Guo-Nan Yin1, Lin Wang2, Xiang-Nan Lin2, Lei Shi2, Zhen-Lin Gao2, Feng-Chan Han3, Ping Li3, Yin-Chuan Jin4, Jun-Kyu Suh1, Ji-Kan Ryu1, Xiong Wang5, Hai-Rong Jin2

1 National Research Center for Sexual Medicine and Department of Urology, Inha University School of Medicine, Incheon 22332, Korea
2 Department of Urology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, China
3 Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, Yantai 264003, China
4 Department of Histology and Embryology, Binzhou Medical University, Yantai, Shandong 264000, China
5 Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China

Correspondence: Dr. HR Jin (jhr2006@163.com) or Dr. X Wang (wx83905@163.com)

Date of Submission 10-Aug-2017 Date of Acceptance 18-Jan-2018 Date of Web Publication 17-Apr-2018


Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects. In the present study, we aimed to test if the combination of SVF and Ad-COMP-Ang1 could extend the erection effect in diabetic ED. We found that the combination therapy showed a long-term effect in restoring erectile function through enhanced penile endothelial and neural cell regeneration. Combination therapy with SVF and Ad-COMP-Ang1 notably restored cavernous endothelial cell numbers, pericyte numbers, endothelial cell–cell junctions, decreased cavernous endothelial cell permeability, and promoted neural regeneration for at least 4 weeks in diabetic mice. In summary, this is an initial description of the long-term effect of combination therapy with SVF and Ad-COMP-Ang1 in restoring erectile function through a dual effect on endothelial and neural cell regeneration. Such combination therapy may have therapeutic potential for the treatment of diabetic ED.

Keywords: angiopoietin-1; erectile dysfunction; neural cell regeneration; stromal vascular fraction

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