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Volume 26, Issue 4 (July 2024) 26, 382–388; 10.4103/aja202378

Relationship between dietary niacin intake and erectile dysfunction: a population-based study

Lin, Wei-Long1; Zheng, Cheng2; Wang, Hao-Xu1; Zhang, Wei1; Lin, Ming-En1

1Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Medical College of Shantou University, Shantou 515041, China
    2The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510260, China

Correspondence: Dr. W Zhang (viagraman@163.com) or Dr. ME Lin (m15917377187@163.com)

30 January 2024


Existing research on the precise link between dietary niacin intake and erectile dysfunction (ED) is scarce. Thus, this study aimed to investigate the potential association between dietary niacin intake and the risk of ED. Multivariate logistic regression and restricted cubic splines (RCSs) were used to examine the relationship between dietary niacin intake and ED. Subgroup interaction analysis was performed to assess the impact of different subgroups on the study outcomes. In addition, 1:1 propensity score matching (PSM) was employed to adjust for potential confounding factors, ensuring the reliability of the results. The analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey (NHANES) in the USA. The study encompassed 3184 adults, among whom 863 participants were identified as having ED. Following adjustments for potential confounders, the findings revealed that higher niacin intake, specifically in the highest tertile, was associated with a decreased risk of ED compared to that in the lowest tertile, showing an odds ratio (OR) of 0.56 (95% confidence interval [CI]: 0.37–0.85). Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of ED. Subgroup and interaction analyses fortified the consistency of these results. Furthermore, PSM corroborated the validity of the findings. This study suggests an inverse association between dietary niacin intake and the risk of ED. However, establishing a cause-and-effect relationship remains elusive, and defining the safe threshold of niacin intake to prevent ED requires further investigation.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.