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Volume 18, Issue 2 (March 2016) 18, 194–201; DOI:10.4103/1008-682X.168788
Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele
Mariana Camargo, Paula Intasqui, Ricardo Pimenta Bertolla
1 Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, R. Embau, 231, 04039-060, Sao Paulo, Brazil
2 Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, R. Embau, 231, 04039-060; Sao Paulo Hospital, Sao Paulo, Brazil
Correspondence: Dr. RP Bertolla (rbertolla@yahoo.com)
04-Dec-2015
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Abstract
Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a "silent" varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as we
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