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Volume 20, Issue 5 (September 2018) 20, 479–487; DOI:10.4103/aja.aja_26_18
Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis
Hai-Tao Ma1,2, Chang-Min Niu1,2, Jing Xia1,2, Xue-Yi Shen1,2, Meng-Meng Xia1,2, Yan-Qiu Hu3, Ying Zheng1,2
1 Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225001, China
2 Jiangsu Key Laboratory of Experimental and Translational Noncoding RNA Research, Yangzhou 225001, China
3 Clinicial Medical College, Yangzhou University, Yangzhou 225001, China
Correspondence: Dr. Y Zheng (yzzkl@163.com)
Date of Submission 31-Oct-2017 Date of Acceptance 27-Feb-2018 Date of Web Publication 29-May-2018
| Abstract |
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To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the first wave of spermatogenesis. Comparisons showed no significant differences in morphology and number of germ cells at 11 days postpartum, while 21 differentially expressed genes (DEGs) associated with spermatogenesis were identified. We speculate that Stra8 performs many functions in different phases of spermatogenesis, such as establishment of spermatogonial stem cells, spermatogonial proliferation and self-renewal, spermatogonial differentiation and meiosis, through direct or indirect regulation of these DEGs. We therefore established a preliminary regulatory network of Stra8 during spermatogenesis. These results will provide a theoretical basis for further research on the mechanism underlying the role of Stra8 in spermatogenesis.
Keywords: differentiation; meiosis; proliferation; spermatogenesis; spermatogonia; Stra8
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