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Abstract

Volume 16, Issue 3 (May 2014) 16, 359–363; doi: 10.4103/1008-682X.126400

Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

Costantine Albany, Noah M Hahn

Indiana University Health, Melvin and Bern Simon Cancer Center, Indianapolis, IN, USA.

Correspondence: Dr. NM Hahn (nhahn@iu.edu)

Received: 19 December 2013; Revised: 13 January 2014; Accepted: 14 January 2014

Abstract

Defects within apoptotic pathways have been implicated in prostate cancer (PCa) tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins (HSPs) and the human androgen receptor (AR), the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.

Keywords: apatorsen; apoptosis; bcl‑2 homologous antagonist‑killer protein; clusterin; custirsen; ganetespib; heat‑shock proteins; prostatic neoplasms

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